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Oropharyngeal and esophageal candidiases remain significant causes of morbidity in human immunodeficiency virus HIV -infected patients, despite the dramatic ability of antiretroviral therapy to reconstitute immunity. Notable advances have been achieved in understanding, at the molecular level, the relationships between the progression of HIV infection, the acquisition, maintenance, and clonality of oral candidal populations, and the emergence of antifungal resistance.
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